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Other Risk Factors

  • obesity in the middle age increases the risk of future dementia; for every one point gain in BMI, the risk of temporal lobe atrophy increased by 13 to 16% [7]

  • homocysteine has been shown to be a risk factor for stroke, heart disease and VaD through its association with small blood vessel and endothelial dysfunction

  • increased levels of homocysteine are a strong independent risk factor for the development of dementia based on the Framingham Study [8]

  • presence of Mild Cognitive Impairment (MCI)


7. Gustafson D, Lissner L, Begtsson C, Bjorkelund C, Skoog I. A 24-year follow-up of body mass index and cerebral atrophy. Neurology 2004; 63:1876-81.

8. Seshadri S, Wolf PA. Homocysteine and the brain: vascular risk factor or neurotoxin? Lancet Neurology Jan; 2(1):11.

All references for this section