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Mixed Type

  • increasing evidence shows that VaD and AD often coexist in older patients and is called mixed dementia

  • cardiovascular disease (CVD) is the pathology and VaD is the disorder  and VaD with no AD pathology is relatively uncommon as shown in the figure below


  • many patients have overlap of AD and significant CVD

  • over 60% of patients diagnosed with AD also have incomplete white matter infarction on imaging [3]

  • cerebral ischemia and amyolid deposits may synergize to produce AD and vascular changes in the brain [4]

  • a great deal of research is currently being conducted to clarify these mechanisms


3. Englund E, Person B. Correlations between histopathologic white matter changes and proton MR relaxation times in dementia. Alzheimer Dis Assoc Disord 1987; 1:156-70.

4. Gorelic PB. Risk factors for vascular dementia and Alzheimer's Disease. Stroke 2004; 35:2620-22.

All references for this section