Compliance is a serious issue for HF patients. Getting them to adhere with sometimes difficult treatment plans can be a challenge. Lack of compliance is also a huge drain on the health care system. For example, one study showed that 64% of readmission cases at one hospital were due to non-compliance with prescribed medication or dietary plans . Another showed that 53% of readmissions at one hospital could have been avoided if the patients had complied with their treatment .
Factors contributing to non-compliance:
Lack of knowledge
Lack of support from family and friends
Lack of a daily reminder routine
Perception that side effects outweigh benefits
Poor outpatient education program
Overall, there is little information available as to gender specific differences in compliance . One study showed that women were more likely to adhere to Digoxin therapy than men were 
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